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Pluristem Therapeutics Inc.

Pluristem Therapeutics Inc.

Medical -




Pluristem Therapeutics Inc. is dedicated to the commercialization of

allogeneic (non-personalized) cellular therapeutics for disorders where

current therapies are inadequate.

Pluristem’s products begin as mesenchymal stromal cells (MSCs)

derived from human placenta, an organ traditionally considered

medical waste and a non-embryonic, non-controversial source

of cells. Pluristem’s MSCs are then grown in a unique (3D)

microenvironment (PluriX bioreactor), without the addition of growth

factors. The MSCs derived from this process are called PLacental

eXpanded (PLX) cells. PLX cells are functionally and immunologically

unique and are stored “ready to use” with no histocompatibility

matching required.

PLX-PAD is intended to treat patients suffering from limb ischemia,

the critical stage of peripheral artery disease (PAD). PLX-PAD targets

those patients whom traditional therapies have not helped and are

potentially facing continued symptoms or amputation. In animals,

PLX-PAD has shown to significantly increase the number of new

blood vessels (angiogenesis) and blood flow in the involved extremity.

Pluristem plans for human studies to begin later in 2008.

PLX-I is intended to help those patients with hematological malignancies

that are unable to find a suitable bone marrow donor match. In animals,

PLX-I, combined with the HSCs found in umbilical cord blood (UCB), has

been shown to significantly increase the engraftment of these HSCs in

bone marrow.

Pluristem believes its PLX cells are also potentially useful for other

disorders such as stroke, Multiple Sclerosis, Crohn’s Disease and

orthopedic injuries. Pluristem is an American public company with

headquarters housing its R&D and GMP-approved manufacturing

facilities in Haifa, Israel.





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