The platform technology is a result of extensive studies on attempts
to form novel liquid nano-vehicles as carriers for non-soluble bioactive
The technology named “NSSL vehicles” (Nano-Sized Self-assembled
Liquid vehicles) is based on formation of curvature-modified swollen
reverse micelles, loaded with insoluble bioactives at their interface.
Upon dilution the vehicles invert (umbrella type) into oil-in-water
nano-droplets and the bioactives, at will, either remain solubilized
or are released in a controlled pattern. The vehicles are embedded
with “membrane recognition enhancers” that help them recognize
membranes and release the bioactives into the bloodstream.
This novel technology can be applied in a variety of other uses such as
environmental protection against oxidation and controlled interfacial
and crystallization processes.
The designed vehicles are used in beverages, cosmetics and mainly
International patents of the technology have been approved and
registered in 2007.
Nutralease, a start-up company, was established (2005) by the
Hebrew University (HU) team headed by Prof. Garti and Yissum – The
HU company for R&D technology, and private investors.
The technology is unique and opens a large scope of options for
utilization of insoluble bioactives and/or poorly adsorbing drugs.
The company sold 200,000 USD worth of products in 2007, and it is
expected that by the year 2009 sales will exceed 2×106 USD.
Several international contracts with leading companies have been
signed. Recently Frutarom – a global Israeli company purchased the
majority of the company’s shares and marketing is presently global.